Cancer Nanotechnology

Basic,Translational and Clinical Research

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  1. Research

    Platinum nanoparticles: an exquisite tool to overcome radioresistance

    Small metallic nanoparticles are proposed as potential nanodrugs to optimize the performances of radiotherapy. This strategy, based on the enrichment of tumours with nanoparticles to amplify radiation effects ...

    Sha Li, Erika Porcel, Hynd Remita, Sergio Marco, Matthieu Réfrégiers, Murielle Dutertre, Fabrice Confalonieri and Sandrine Lacombe

    Cancer Nanotechnology 2017 8:4

    Published on: 11 July 2017

  2. Review

    An overview of current practice in external beam radiation oncology with consideration to potential benefits and challenges for nanotechnology

    Over the past two decades, there has been a significant evolution in the technologies and techniques employed within the radiation oncology environment. Over the same period, extensive research into the use of...

    Raymond B. King, Stephen J. McMahon, Wendy B. Hyland, Suneil Jain, Karl T. Butterworth, Kevin M. Prise, Alan R. Hounsell and Conor K. McGarry

    Cancer Nanotechnology 2017 8:3

    Published on: 3 February 2017

  3. Review

    Biological mechanisms of gold nanoparticle radiosensitization

    There has been growing interest in the use of nanomaterials for a range of biomedical applications over the last number of years. In particular, gold nanoparticles (GNPs) possess a number of unique properties...

    Soraia Rosa, Chris Connolly, Giuseppe Schettino, Karl T. Butterworth and Kevin M. Prise

    Cancer Nanotechnology 2017 8:2

    Published on: 2 February 2017

  4. Review

    Application of nanotechnology to cancer radiotherapy

    Radiotherapy has been an integral treatment modality for cancer. The field arose from and progressed through innovations in physics, engineering, and biology. The evolution of radiation oncology will rely on t...

    Yu Mi, Zhiying Shao, Johnny Vang, Orit Kaidar-Person and Andrew Z. Wang

    Cancer Nanotechnology 2016 7:11

    Published on: 19 December 2016

  5. Research

    Profiling lung adenocarcinoma by liquid biopsy: can one size fit all?

    Cancer is first and foremost a disease of the genome. Specific genetic signatures within a tumour are prognostic of disease outcome, reflect subclonal architecture and intratumour heterogeneity, inform treatme...

    Harry W. Clifford, Amy P. Cassidy, Courtney Vaughn, Evaline S. Tsai, Bianka Seres, Nirmesh Patel, Hannah L. O’Neill, Emil Hewage and John W. Cassidy

    Cancer Nanotechnology 2016 7:10

    Published on: 22 November 2016

  6. Review

    Gold nanoparticles for cancer radiotherapy: a review

    Radiotherapy is currently used in around 50% of cancer treatments and relies on the deposition of energy directly into tumour tissue. Although it is generally effective, some of the deposited energy can advers...

    Kaspar Haume, Soraia Rosa, Sophie Grellet, Małgorzata A. Śmiałek, Karl T. Butterworth, Andrey V. Solov’yov, Kevin M. Prise, Jon Golding and Nigel J. Mason

    Cancer Nanotechnology 2016 7:8

    Published on: 3 November 2016

  7. Methodology

    Intravital microscopy for evaluating tumor perfusion of nanoparticles exposed to non-invasive radiofrequency electric fields

    Poor biodistribution and accumulation of chemotherapeutics in tumors due to limitations on diffusive transport and high intra-tumoral pressures (Jain RK, Nat Med. 7(9):987–989, 2001) have prompted the investigati...

    Norman A. Lapin, Martyna Krzykawska-Serda, Matthew J. Ware, Steven A. Curley and Stuart J. Corr

    Cancer Nanotechnology 2016 7:5

    Published on: 30 June 2016

  8. Research

    Nanotechnology and cancer: improving real-time monitoring and staging of bladder cancer with multimodal mesoporous silica nanoparticles

    Despite being one of the most common cancers, bladder cancer is largely inefficiently and inaccurately staged and monitored. Current imaging methods detect cancer only when it has reached “visible” size and ha...

    Sean K Sweeney, Yi Luo, Michael A O’Donnell and Jose Assouline

    Cancer Nanotechnology 2016 7:3

    Published on: 27 April 2016

  9. Research

    Bio-conjugation of antioxidant peptide on surface-modified gold nanoparticles: a novel approach to enhance the radical scavenging property in cancer cell

    Functionalized gold nanoparticles are emerging as a promising nanocarrier for target specific delivery of the therapeutic molecules in a cancer cell, as a result it targeted selectively to the cancer cell and ...

    Sushma Kalmodia, Suryanarayanan Vandhana, B. R. Tejaswini Rama, Balasubramanyam Jayashree, T. Sreenivasan Seethalakshmi, Vetrivel Umashankar, Wenrong Yang, Colin J. Barrow, Subramanian Krishnakumar and Sailaja V. Elchuri

    Cancer Nanotechnology 2016 7:1

    Published on: 9 February 2016

  10. Research

    AGuIX nanoparticles as a promising platform for image-guided radiation therapy

    AGuIX are gadolinium-based nanoparticles developed mainly for imaging due to their MR contrast properties. They also have a potential role in radiation therapy as a radiosensitizer. We used MRI to quantify the...

    Alexandre Detappe, Sijumon Kunjachan, Joerg Rottmann, James Robar, Panagiotis Tsiamas, Houari Korideck, Olivier Tillement and Ross Berbeco

    Cancer Nanotechnology 2015 6:4

    Published on: 2 September 2015

  11. Review

    DNA vaccination for prostate cancer: key concepts and considerations

    While locally confined prostate cancer is associated with a low five year mortality rate, advanced or metastatic disease remains a major challenge for healthcare professionals to treat and is usually terminal....

    Grace Cole, Joanne McCaffrey, Ahlam A. Ali and Helen O. McCarthy

    Cancer Nanotechnology 2015 6:2

    Published on: 2 July 2015

  12. Research

    Exploratory use of docetaxel loaded acid-prepared mesoporous spheres for the treatment of malignant melanoma

    Five year survival for metastatic melanoma (MM) is very low at <10%. Therapeutic options have been limited secondary to systemic toxicity. As a result there has been a growing movement towards developing targe...

    Sameer Kaiser, Maximilian B MacPherson, Ted A James, Albert Emery, Page Spiess, Albert van der Vliet, Christopher C Landry and Arti Shukla

    Cancer Nanotechnology 2015 6:1

    Published on: 24 January 2015

  13. Research

    Contact-mediated intracellular delivery of hydrophobic drugs from polymeric nanoparticles

    Encapsulation of drugs in nanoparticles can enhance the accumulation of drugs in tumours, reduce toxicity toward healthy tissue, and improve pharmacokinetics compared to administration of free drug. To achieve...

    Sofie Snipstad, Sara Westrøm, Yrr Mørch, Mercy Afadzi, Andreas KO Åslund and Catharina de Lange Davies

    Cancer Nanotechnology 2014 5:8

    Published on: 6 December 2014

    The Erratum to this article has been published in Cancer Nanotechnology 2015 6:3

  14. Research

    Cell localisation of gadolinium-based nanoparticles and related radiosensitising efficacy in glioblastoma cells

    Recently, the addition of nanoparticles (NPs) has been proposed as a new strategy to enhance the effect of radiotherapy particularly in the treatment of aggressive tumors such as glioblastoma. The physical pro...

    Lenka Štefančíková, Erika Porcel, Pierre Eustache, Sha Li, Daniela Salado, Sergio Marco, Jean-Luc Guerquin-Kern, Matthieu Réfrégiers, Olivier Tillement, François Lux and Sandrine Lacombe

    Cancer Nanotechnology 2014 5:6

    Published on: 10 October 2014

  15. Research

    Advantages of gadolinium based ultrasmall nanoparticles vs molecular gadolinium chelates for radiotherapy guided by MRI for glioma treatment

    AGuIX nanoparticles are formed of a polysiloxane network surrounded by gadolinium chelates. They present several characteristics. They are easy to produce, they present very small hydrodynamic diameters (<5 nm...

    Géraldine Le Duc, Stéphane Roux, Amandine Paruta-Tuarez, Sandrine Dufort, Elke Brauer, Arthur Marais, Charles Truillet, Lucie Sancey, Pascal Perriat, François Lux and Olivier Tillement

    Cancer Nanotechnology 2014 5:4

    Published on: 1 July 2014

  16. Research

    Effective cellular internalization of silica-coated CdSe quantum dots for high contrast cancer imaging and labelling applications

    The possibility of developing novel contrast imaging agents for cancer cellular labelling and fluorescence imaging applications were explored using silica-coated cadmium selenide (CdSe) quantum dots (QDs). The...

    Muthunayagam Vibin, Ramachandran Vinayakan, Annie John, Francis Boniface Fernandez and Annie Abraham

    Cancer Nanotechnology 2014 5:1

    Published on: 27 June 2014

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